For Home Defense, a G34 with a Surefire X300 attached is about perfect. Holsters for guns with lights attached are available from most makers. I like Safariland's ALS series. Like a #6377-683-131 for example. (I think I got the numbers right, mine has a different middle number for the G19)

I CCW a G19, and I also used to be certified as a Glock Armorer, but let it lapse.